College Basketball on TNT Sports broadcasts a variety of events across its networks, including the NCAA Division I Men's Basketball Tournament, Acrisure Classic, and Players Era Festival. The network's involvement began with early, high-profile games on TBS in 1982 and 1983, featuring legendary players like Ralph Sampson and Patrick Ewing. Its college basketball presence dramatically expanded in 2010 with a landmark 14-year, US$10.8 billion agreement with the NCAA and CBS for joint broadcast rights to the Men's Tournament, a deal later extended through 2032.

This arrangement distributes tournament games across CBS, TBS, TNT, and truTV, with the Final Four and Championship game alternating between Turner and CBS since 2016. In recent years, TNT Sports has further broadened its coverage, reintroducing regular season games via NBA TV starting in 2021 and notably expanding its dedication to Historically Black Colleges and Universities (HBCU) basketball with events like the Invesco QQQ Legacy Classic and NBA-HBCU Classic.