The New England Journal of Medicine (NEJM), founded in 1812 and published by the Massachusetts Medical Society, is a prestigious peer-reviewed medical journal with an impact factor of 96.2 (2023).

Historical Significance and Influence: - Published notable articles including the first report of anesthesia use in 1846, the discovery of platelets in 1906, and landmark research on leukemia treatment in 1948 and heart resuscitation in 1952. - In 2020, its editors published an unprecedented editorial condemning the Trump administration's handling of the COVID-19 pandemic. - Recognized for its rigorous editorial standards, including the "Ingelfinger rule" prohibiting pre-publication release of research without peer review.