The 2021 Northwestern State Lady Demons softball team, coached by Donald Pickett in his 13th season, competed in the NCAA Division I Southland Conference and played home games at Lady Demon Diamond. In the preseason coaches' poll released on February 5, 2021, they were projected to finish sixth, earning 156 votes and a single first-place vote. The squad featured multiple preseason All-Southland selections, including first-team honorees Cayla Joens, Elise Vincent, and E.C. Delafield, while Alexis Perry and Hayley Barbazon earned second-team nods. Although the article outlines the team's roster and schedule, specific game outcomes are not detailed. The season's top conference awards ultimately went to other teams, with Kassidy Wilbur of SFA winning Player and Pitcher of the Year, and Nicole Dickson of SFA being named Coach of the Year. Overall, this summary highlights the team's preseason standing and key personnel for the 2021 campaign.