The Johns Hopkins University School of Medicine (JHUSOM), situated in Baltimore, Maryland, is a premier medical school associated with Johns Hopkins University. Established in 1893 alongside the Johns Hopkins Hospital, it rapidly gained acclaim as a global hub for biomedical research and innovation, consistently ranking among the top medical schools in the United States. JHUSOM is a fundamental part of the extensive Johns Hopkins Medicine health system, sharing its East Baltimore campus with the Johns Hopkins Hospital – its main teaching hospital – the School of Nursing, and the Bloomberg School of Public Health, and maintaining affiliations with numerous other regional medical centers.

The school's inception was rooted in the forward-thinking vision of Baltimore philanthropist Johns Hopkins, who, prior to his death in 1873, conceived a university and hospital inextricably linked by a medical school – a groundbreaking concept at the time. After the hospital's opening in 1889, financial constraints threatened the medical school's establishment. However, a nationwide fundraising campaign spearheaded by four daughters of the original trustees, most notably Mary Elizabeth Garrett, secured the necessary funds. This funding came with a revolutionary condition: the medical school must admit both men and women, challenging the era's prevalent exclusion of women from medical education. Consequently, three women were among the first class when JHUSOM officially opened in 1893. Its foundational excellence was cemented by its distinguished first faculty, including pathologist William Henry Welch (the first dean), internist William Osler (author of a seminal medical textbook), surgeon William Stewart Halsted (pioneer of aseptic technique), and gynecological surgeon Howard Atwood Kelly (credited with establishing gynecology as a specialty).

JHUSOM's profound influence extends to shaping medical education across the United States, serving as the model recognized by the Flexner Report. Its major teaching hospital, the Johns Hopkins Hospital, was consistently ranked the top hospital in the U.S. for two decades. The medical school itself continues to receive high accolades, ranking #2 nationally for Research and #1 in several key specialties, including Anesthesiology and Surgery, by U.S. News & World Report in 2024. Academically, medical students participate in a distinctive "Colleges Advisory Program," where they are divided into four colleges named after influential Hopkins faculty members. This program fosters a supportive learning environment, with faculty advisors guiding students throughout their four years, and culminates annually in the "College Olympics" for inter-college competition.

The School of Medicine boasts a remarkable legacy of scientific breakthroughs and influential figures. As of 2024, 15 Nobel laureates are specifically affiliated with JHUSOM, including 14 of the university's 17 Nobel laureates in Physiology or Medicine, underscoring its immense contributions to medical science, with Peter Agre and Gregg Semenza as current faculty laureates. Its alumni and faculty have also pioneered fields ranging from cardiology to neurosurgery, and include figures like the "father of CPR," James Jude, and former CDC Director Rochelle Walensky. In a significant philanthropic gesture, businessman and former New York City mayor Michael Bloomberg announced a $1 billion gift in July 2024, aimed at making tuition free for medical students whose families earn under $300,000 annually, starting in Fall 2024. The school's impactful work has also been highlighted in popular culture, notably through the Peabody Award-winning ABC documentary series Hopkins and the acclaimed film Something the Lord Made.