Coco Gauff captured the women's singles title at the 2026 Cincinnati Open, defeating fellow American Jessica Pegula in the final with a score of 6–2, 6–4. This victory marked Gauff's second Cincinnati title (after 2023), her fourth WTA 1000 title, and her twelfth career WTA Tour title, making her only the third woman in the Open Era to win multiple Cincinnati singles titles, alongside legends Serena Williams and Victoria Azarenka. The final was historic as it was the first all-American women's singles final at the tournament since 1970. Defending champion Iga Świątek was eliminated in the semifinals by Pegula, while Aryna Sabalenka retained the WTA No. 1 ranking after Elena Rybakina retired in the quarterfinals. The tournament, held one week later than usual, featured all seeded players receiving byes into the second round.