The 2021 NCAA Division I Baseball Tournament, the 74th edition, saw Mississippi State make history by defeating Vanderbilt in the best-of-three final series to claim their program's first-ever national championship. This 64-team competition kicked off on June 4, 2021, and culminated with the College World Series in Omaha, Nebraska, concluding on June 30.

Teams advanced through a rigorous multi-stage format, beginning with 16 regional double-elimination tournaments, followed by best-of-three Super Regionals, to determine the eight participants in Omaha. Notably, several teams including Grand Canyon, NJIT, Norfolk State, and Presbyterian made their tournament debuts after securing their first conference titles. The tournament also adapted to COVID-19 precautions, which influenced hosting selections and led to the unusual circumstance of a national seed, Old Dominion, playing their regional on the road.