The Houston Marathon is an annual event held every January since 1972, recognized as the city's largest single-day sporting event, drawing nearly half a million spectators and thousands of runners for its marathon, half marathon, and 5K races. It boasts a significant history, having hosted the U.S. Olympic Marathon Trials for both men and women in 2012 and featuring a unique 2007 satellite run simultaneously held in Fallujah, Iraq. Notable participants include George W. Bush, who completed the marathon in 1993 with a time of 3 hours, 44 minutes, and 52 seconds.

The event's fast, flat, USATF-certified course through scenic Houston areas makes it a popular choice for runners aiming to qualify for the Boston Marathon. Beyond the competition, the marathon supports various local charities. Many national records have been set at the Houston Marathon, further solidifying its prestige in the running community.