The name Paul Reed is associated with a diverse group of notable Americans across various fields, spanning politics, arts, sports, and music. Historically, P. Booker Reed (1842–1913) held the significant position of mayor of Louisville, Kentucky.

The arts are well-represented by figures like Paul Reed (1919–2015), a prominent American artist, and Paul Reed (1909–2007), an actor known for his stage and screen work. More contemporary individuals include American basketball player Paul Reed (born 1999) and the late writer Paul Reed (1956–2002). Perhaps most widely recognized in the music industry is Paul Reed Smith (born 1956), a master luthier and the acclaimed founder of PRS Guitars, a globally renowned instrument manufacturer.