The surname Vicario is associated with a diverse array of accomplished individuals, primarily from Italy but also with significant international recognition. Historically, a standout figure is Leona Vicario (1789–1842), a crucial Mexican revolutionary and heroine. In the realm of arts and entertainment, the name is associated with Italian talents such as Marco Vicario (1925–2020), a versatile film actor, director, and producer, and Margherita Vicario (born 1988), a successful singer, songwriter, and actress.

The sporting world also features numerous Vicarios, including Italian bobsledder Enzo Vicario and footballers Guglielmo and Jaron Vicario. Expanding its reach, the renowned Spanish tennis star Arantxa Sánchez Vicario also carries the name, with "El Vicario" even identifying a winery in Spain, showcasing its presence across various fields and geographies.