The 2022 Angel City FC season marked the team's historic inaugural campaign in the National Women's Soccer League (NWSL), the top tier of women's soccer in the United States. A significant front-office change occurred on August 15, 2022, when the club promoted Angela Hucles to general manager, taking over some duties from sporting director Eniola Aluko. On the pitch, the team struggled to find consistency, finishing the regular season in eighth place and failing to qualify for the NWSL playoffs, while also exiting the NWSL Challenge Cup during the group stage. Despite the overall results, the squad showcased attacking talent, scoring 25 goals across all competitions, with Savannah McCaskill leading the way as the top scorer with 7 goals, followed by Christen Press and Cari Roccaro with 4 each. Off the field, the club made international headlines by announcing a two-year partnership with Tigres UANL of Liga MX Femenil and hosting the inaugural Copa Angelina friendly against the Mexico women's national team on September 5, 2022, which Mexico won 2–0. Ultimately, the season laid a strong foundation for the expansion franchise, highlighted by its community engagement and ambitious global partnerships.