The 2025 season marked Nashville SC's sixth in Major League Soccer and their eighth overall, featuring B.J. Callaghan in his first full year as head coach after taking over in July 2024. Following a dismal 2024 campaign (9–9–16) that saw them miss the playoffs, the team underwent a significant roster overhaul, releasing long-time players Aníbal Godoy and Brian Anunga, who had been with the club since its MLS debut in 2020. The regular season, which ran from February to October, consisted of 34 matches (17 home, 17 away) primarily against Eastern Conference opponents, with six games against Western Conference teams. League play took a hiatus from June 14 to 25 due to the 2025 FIFA Club World Cup and the CONCACAF Gold Cup, both hosted in the United States. The schedule was unveiled on December 19, 2024, and the active roster was set as of April 1, 2025, paving the way for a fresh start under new leadership.