RC Strasbourg Alsace entered its 120th season in 2025–26, marking its ninth consecutive campaign in Ligue 1 while also competing in the Coupe de France and the UEFA Conference League. The club impressed in Europe, finishing top of the Conference League league phase with five wins and a draw, which secured direct advancement to the round of 16. Domestically, the team's Ligue 1 schedule was affected by its European run, as Matchday 29 against Brest was postponed due to the Conference League commitments. Off the pitch, a notable development occurred on 6 January 2026, when fellow BlueCo-owned club Chelsea appointed Liam Rosenior as their new head coach, linking the two sister clubs. Key draw dates included the Conference League play-off round draw on 4 August 2025 and the round of 16 draw on 27 February 2026, with the squad roster finalized as of 2 February 2026. The season featured a full first-team squad and loan activity, with the club aiming to build on its strong European form while navigating the domestic league and cup competitions.