Eli Lilly and Company, founded in 1876 by Civil War veteran and chemist Eli Lilly in Indianapolis, is a global pharmaceutical powerhouse whose products reach about 125 countries. In November 2025, it made history by becoming the first healthcare company to reach a $1 trillion market capitalization, solidifying its status as the world's most valuable pharmaceutical firm. Its current success is largely driven by tirzepatide (sold as Mounjaro and Zepbound) for diabetes and weight loss, which alone accounts for over half of its revenues. Historically, Lilly was the first to mass-produce the polio vaccine (1955) and insulin, and pioneered human insulin using recombinant DNA. The company also created iconic blockbuster drugs like Prozac and Cymbalta, while the founding family's charitable Lilly Endowment still owns a significant stake in the business.