The name Wirtz primarily refers to an influential American business family, whose patriarch Arthur Wirtz (1901–1983) founded the Wirtz Corporation, famously known for its long-standing ownership of the NHL's Chicago Blackhawks and, for a time, the NBA's Chicago Bulls. His descendants, including Bill, Rocky, and Danny Wirtz, have continued this legacy, while numerous other individuals named Wirtz have achieved prominence in diverse fields.

Notable figures include W. Willard Wirtz (1912–2010), a distinguished U.S. cabinet officer, and Carl Wilhelm Wirtz (1876–1939), a German astronomer after whom a crater on Mars is named. The name also belongs to Florian Wirtz (born 2003), a rising German football star, the acclaimed Belgian landscape gardener Jacques Wirtz (1924–2018), and Canadian Olympic figure skaters Kris and Sean Wirtz. Geographically, Wirtz denotes a populated place in Virginia, USA, alongside the aforementioned impact crater on Mars.